Table 2.
Risk Factors for Herpes Simplex Virus (HSV) Genital Shedding or Clinical Recurrence
| Total HSV shedding |
Subclinical HSV shedding |
Genital lesions |
||||
| Risk factor | Univariate | Multivariate | Univariate | Multivariate | Univariate | Multivariate |
| Time since first genital herpes episodea | ||||||
| 1-9 years vs <1 year | .71 (.59–.85);P <.001 | .72 (.60–.86); P<.001 | .59 (.47–.74); P<.001 | .59 (.47–.75); P<.001 | .87 (.66–1.15); P=.33 | .90 (.69–1.17); P=.44 |
| 10 or more years vs <1 year | .52 (.42–.64); P<.001 | .57 (.45–.72):P<.001 | .38 (.29–.50); P<.001 | .41 (.30–.56); P<.001 | .74 (.55–.99); P=.05 | .87 (.62–1.21); P=.41 |
| Racea: Nonwhite vs white | .52 (.35–.77); P=.001 | .54 (.37–.78); P=.001 | .64 (.41–1.01);P=.05 | .67 (.44–1.01);P=.05 | .45 (.27–.78);P=.004 | .46 (.27–.79);P=.005 |
| Age,a year | .98 (.97–.99); P<.001 | .99 (.98–1.00); P=.20 | .98 (.97–.99);P<.001 | .99 (.98–1.00);P=.36 | .98 (.97–.99);P=.01 | .99 (.98–1.00);P=.06 |
| Gender: Female vs Male | 1.1 (.89–1.29); P=.47 | – | 1.15 (.90–1.47); P=.27 | – | 1.04 (.89–1.29); P=.75 | – |
| Homosexual (MSM, WSW) vs heterosexual | .81 (.60–1.1); P=.17 | – | .75 (.51–1.10) P=.15 | – | .82 (.55–1.21); P=.32 | – |
| Age at first sex:>=18 vs <18 | 1.0 (.85–1.29);P=.68 | – | 1.16 (.89–1.53):P=.25 | – | .92 (.70–1.21); P=.55 | – |
| HSV antibody status: HSV-1 and HSV-2 vs HSV-2 only | .98 (.81–1.18);P=.82 | – | .92 (.72–1.17):P=.50 | – | .93 (.72–1.18); P=.54 | – |
NOTE. Data are incidence rate ratio (95% confidence interval); P-value unless otherwise indicated.
a
Significant variables used in multivariate analysis bolded.