Table 3.

Hazard ratios (95% confidence intervals) for onset of breast development, pubic hair growth, and menarche.^†

	Model 1 Unadjusted	Model 2a Age Adjusted	Model 3b Adjusted
Breast Development
Tobacco Use	0.74 (0.65-0.85)	0.86 (0.74-0.98)	0.91 (0.79-1.06)
Alcohol Use	0.71 (0.57-0.88)	0.81 (0.66-1.00)	0.84 (0.67-1.05)
Body Hair Growth
Tobacco Use	0.81 (0.71-0.93)	0.91 (0.80-1.04)	0.92 (0.79-1.06)
Alcohol Use	0.97 (0.81-1.16)	1.07 (0.89-1.29)	1.12 (0.91-1.37)
Menarche
Tobacco Use	0.90 (0.76-1.06)	0.85 (0.72-1.01)	0.94 (0.78-1.14)
Alcohol Use	0.90 (0.75-1.07)	0.85 (0.71-1.02)	0.92 (0.75-1.12)

^†In all models, standard errors are corrected using heteroskedasticity-consistent covariance matrix estimator that does not assume independent cases within clusters (families).

^aAdjusted for age.

^bAdjusted for the other substance, age, and race, parental income, parental education.