Table 3.
Distribution of Combined 10-Year CHD* and Lifetime CVD Predicted Risk Strata in the CVD-free, Nondiabetic, Nonpregnant, 20- to 79-Year Old U.S. Population - With Obesity† and Low HDL Cholesterol‡ Included as Major Risk Factors
| n | Weighted, n | Percentage (SE) of U.S. Population in Risk Stratum | p | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Low 10-Year CHD*/Low Lifetime CVD Predicted Risk | Low 10-Year CHD*/High Lifetime CVD Predicted Risk | High 10-Year CHD* Predicted Risk | |||||||
| All Optimal | ≥1 Not Optimal | ≥1 Elevated | 1 Major | ≥2 Major | |||||
| Neither included | 6,329 | 156,100,000 | 11.4 (0.4) | 15.1 (0.7) | 17.5 (0.7) | 29.7 (0.7) | 8.3 (0.5) | 18.0 (0.8) | |
| Both included | 6,329 | 156,100,000 | 7.5 (0.4) | 8.7 (0.6) | 10.1 (0.7) | 29.0 (0.8 | 26.7 (0.9) | 18.0 (0.8) | <0.001 |
| Obesity only | 6,329 | 156,100,000 | 9.2 (0.4) | 10.4 (0.7) | 11.8 (0.7) | 33.2 (0.8) | 17.4 (0.7) | 18.0 (0.8) | <0.001 |
| Low HDL-C only | 6,329 | 156,100,000 | 8.6 (0.4) | 11.4 (0.6) | 13.8 (0.7) | 31.8 (0.9) | 16.3 (0.7) | 18.0 (0.8) | <0.001 |
*
10-year hard coronary heart disease risk calculated based on D’Agostino et al,10 with “low” defined as <10% 10-year predicted CHD risk and absence of diabetes.
†
Obesity defined as BMI ≥30 kg/m2
‡
Low HDL-C defined as <40 mg/dL for men and <50 mg/dL for women
p is for the comparison to the stratification without HDL-C and obesity included.
SE=standard error, CHD=coronary heart disease, CVD=cardiovascular disease, HDL-C=high-density lipoprotein cholesterol.