Figure 2. 2′-O methylation of viral RNA alters the sensitivity of WNV to the antiviral effects of IFN.
a, IFN-β gene induction in Ifnar1−/− MEF after WNV-WT or WNV-E218A infection. Results are representative of three independent experiments performed in duplicate. b, Viral replication in IPS-1−/− MEF after IFN-β pretreatment. The data are the average of two independent experiments performed in triplicate, and the asterisks indicate differences that are statistically significant (***P < 0.0001; **P < 0.005; *P < 0.05). Error bars, s.d. IU, international units.