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Fig. 7. Regulation of cellular protein synthesis by P56. Transcription of 561 mRNA is induced by IFN or virus/dsRNA using two different signaling pathways. P56, produced upon translation of 561 mRNA, binds to the P48 subunit of eIF-3 and blocks its function in peptide chain initiation. As a result, synthesis of cellular proteins, including that of P56 itself, is inhibited.
