Table 4.
Biological Effect of Argutins A-H (1-8) with and without TRAIL
| Compound | EC50 w/ TRAIL (μM) | EC50 w/o TRAIL (μM) | Synergistic Effecta |
|---|---|---|---|
| argutin A (1) | 2.4 | 5.4 | 2.3 |
| argutin B (2) | 4.6 | 13.8 | 3.0 |
| argutin C (3) | 1.6 | 3.1 | 1.9 |
| argutin D (4) | 8.7 | 14.3 | 1.6 |
| argutin E (5) | 2.2 | 3.3 | 1.5 |
| argutin F (6) | 7.1 | 10.4 | 1.5 |
| argutin G (7) | 2.8 | 4.2 | 1.5 |
| argutin H (8) | 9.8b | 12.6b | 1.3 |
a
Synergistic effect is defined as the ratio of the two half-maximal (EC50) values obtained from cell killing curves.
b
EC50 is estimated. Argutin H contains impurities and was isolated in small quantities; further purification would have resulted in loss of material.