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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Ann N Y Acad Sci. 2010 Nov 22;1217:83–95. doi: 10.1111/j.1749-6632.2010.05826.x

Figure 2.

Figure 2

Proposed signal transduction pathways following NK-1 receptor activation. Functional interaction of substance P with the NK-1 receptor stimulates NK-1 receptor-mediated CDP/CTP exchange on the Gaq subunit and the subsequent activation of PLC β (phospholipase C β). The two intracellular second messengers, IP3 (inositol 1,4,6-triphosphate) and DAG (diacylgylcerol), then stimulate the mobilization of intracellular Ca2+ and the activation of PKC (protein kinase C), respectively. Current interest is focusing on the possible gene regulatory effects of G protein-coupled receptor activation mediated by the Gργ subunits. [Orignally published in Bremer & Leeman (2010). Reproduced with permission.]