Table III.
Genes of the cardiovascular system
| Gene | Polymorphisms | Number of studies* |
|
|---|---|---|---|
| Associated | Not associated | ||
| ACE | insertion/deletion intron 16 (rs4646994) | 4 (2)103–106 | 7 (4)101–103, 107,108§ |
| AGT | rs699 | 1 (1)107 | 2 (2)107 |
| AGTR1 | rs5186 | 2 (2)107 | 3 (3)105, 107, 109 |
| BDKRB2 | rs5223 | 3 (3)107 | |
| APOB | ApoB (Xbal) | 1 (0)47 AAA vs AAA+PAA | |
| APOE | APO E3E3 and E3E4 | 1 (0)113 AAA expansion | 1 (1)114 AAA expansion |
| rs405509, rs429358, rs4420638, rs7412, rs8106922 | 1 (1)114 | ||
| CETP | TaqIA RFLP | 1 (0)42 | |
| F2 | FII G20210A | 1 (1)115 | |
| F5 | Factor V Leiden | 1 (1)115 | |
| MTHFR | rs1801133 | 4 (0)120–123 | 6 (3)115, 118, 123–126 |
| rs1801131 | 1 (0)126 male and non-smoker | 2 (1)125, 126 | |
| rs2274976, rs48846049 | 1 (1)125 | ||
| MTHFD1 | rs8003379 | 1 (1)125 | |
| rs2357481, rs1076991, rs3783732, rs1950902, rs4902283, rs2236225 | 1 (1)125 | ||
| MTR | rs2853523 | 1 (1)125 | |
| rs4659725, rs1805087, rs2275566, rs6676866 | 1 (1)125 | ||
| MTRR | rs326118 | 1 (1)125 | |
| rs1801394, rs1532268, rs2303080, rs10064631, rs16879334, rs8659 | 1 (1)125 | ||
| TYMS | rs16430 | 1 (1)125 | |
| rs502396 | 1 (1)125 | ||
| ENOSF1 | rs8423 | 1 (1)125 | |
| AHCY | rs819149, | 1 (1)125 | |
| rs7271501 | 1 (1)125 | ||
| FOLH1 | rs202680 | 1 (0)125 subgroup AAA diameter | 1 (1)125 |
| rs202676 | 1 (1)125 | ||
| BHMT | rs651852, rs567754, rs3733890, rs585800 | 1 (1)125 | |
| BHMT2 | rs644191, rs682985 | 1 (1)125 | |
| CBS | 8344 C>T, 1542 C>T, 3753 C>T, 3758 G>A, rs1051319 | 1 (1)125 | |
| NNMT | rs566775, rs10891639, rs4646335, rs3819100 | 1 (1)125 | |
| PON1 | −108 C>T | 1 (0)126 only > 65 years and smoker | 1 (0)126 |
| rs854560, rs662, rs3917594 | 1 (1)125 | ||
| PON2 | rs12026 | 1 (1)125 | |
| SLC19A1 | rs3788205, rs3177999, rs1051266 | 1 (1)125 | |
| SHMT1 | rs638416, rs1979277 | 1 (1)125 | |
| TCN2 | rs5749131, rs1801198, rs10418 | 1 (1)125 | |
| NOS3 | Intron 4 27–bp repeat (4a/4b) | 2 (1)135, 141 | |
| 894 G>T | 2 (1)135, 136 | ||
| −786 T>C | 1 (1)135 | ||
| PTGS2 | rs20417, rs4648307 | 1 (1)146 | |
| HP | Variant α-chains α1/α2 | 2 (0)42, 148 one study on AAA expansion | 2 (0)44, 147 in 28 AAA families |
|
Blood groups | |||
| ABO | A | 1 (0)12 117/59862 |
|
| RHD/d | Rh- | 1 (0)12 | |
| KEL | positive | 1 (0)12 | |
| MNS | MNss | 1 (0)12 | |
*
Number in parenthesis indicates the number of studies with a sample size of at least 150 cases and 150 controls.
§
Study with 1,000 cases and controls
If multiple sample sets were used in one publication, they were treated as independent studies. AAA, abdominal aortic aneurysm; PAA, popliteal artery aneurysm
Gene symbols available from the National Center for Biotechnology Information (NCBI; http://www.ncbi.nlm.nih.gov/) were used.