Table 1.
Clinicopathologic features of the human cases exhibiting direct in situ LVI without stromal invasion compared to agematched and size-matched controls.
| Feature | Cases | Controls | Significance |
|---|---|---|---|
| Breast appearance | ---- | ---- | ---- |
| Redness | 0/10 | 0/10 | p=.5 |
| Edema | 0/10 | 0/10 | p=.5 |
| Nipple retraction | 0/10 | 0/10 | p=.5 |
| Mammographic appearance | ---- | ---- | ---- |
| Abnormal microcalcifications | 9/10 | 8/10 | p=.5 |
| Abnormal density | 9/10 | 9/10 | p=.5 |
| Size (diameter) | 1-5 cm | 1-5 cm | p=.5 |
| Previous FNA | 1/10 | 2/10 | p=.1 |
| Previous core biopsy | 3/10 | 4/10 | p=.1 |
| Concurrent sentinel node procedure | 4/10 | 6/10 | p=.1 |
| Subsequent sentinel node procedure | 6/10 | 4/10 | p=.1 |
| Grade of DCIS | ---- | ---- | ---- |
| Low | 1/10 | 2/10 | p=.5 |
| Intermediate | 3/10 | 3/10 | p=.5 |
| High | 6/10 | 5/10 | p=.5 |
| Stromal invasion | 0/10 | 0/10 | p=.5 |
| Lymphovascular invasion | 10/10 | 0/10 | p=.01 |
| Paget's disease of nipple | 2/10 | 1/10 | p=.5 |
| Axillary lymph node status | ---- | ---- | ---- |
| Positive sentinel node | 7/10 | 1/10 | p=.01 |
| Positive additional nodes | 3/10 | 0/10 | p=.01 |
| Biomarker profile | ---- | ---- | ---- |
| ER +, PR +, Her-2/neu − | 3/10 | 3/10 | p=.5 |
| ER +, PR −, Her-2/neu − | 1/10 | 2/10 | p=.5 |
| ER −, PR +, Her-2/neu − | 1/10 | 0/10 | p=.5 |
| ER−, PR −, Her-2/neu + | 3/10 | 3/10 | p=.5 |
| Triple negative | 2/10 | 2/10 | p=.5 |
| Surgical procedure | ---- | ---- | ---- |
| Lumpectomy | 8/10 | 9/10 | p=.5 |
| Mastectomy | 2/10 | 1/10 | p=.5 |