Table 2.
Tumor Clustera | DCIS | LVI | t-test |
---|---|---|---|
E-cadherinb | 95±5% | 93±6% | p=0.5 |
Ki-67c | 23±4% | 25±8% | p=0.5 |
Size (perimeter)d | 1221μ±180 | 1084μ±160 | p=0.1 |
Shape (elongation ratio)e | 0.85±.10 | 0.70±.05 | p=.05 |
100 clusters of DCIS and tumor emboli were individually analyzed for the given immunoreactivity or morphometric measurement and expressed as Mean ± SD. Differences were analyzed with the Student's t-test.
E-cadherin immunoreactivity was measured as the percentage of tumor cells exhibiting membrane positivity.
Ki-67 immunoreactivity was measured as the percentage of tumor cells exhibiting nuclear positivity.
Size was measured as the perimeter of the DCIS clusters or lymphovascular tumor emboli and analyzed with ImageJ algorithms.
Shape was measured as the elongation ratio (ratio of short to long axis) of the DCIS clusters or lymphovascular tumor emboli and analyzed with standard imaging algorithms.