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Bnip3 induces mitochondrial autophagy in Bax/Bak DKO MEFs. Cells were infected with β-gal or Bnip3 plus and GFP-LC3. (a) GFP-LC3 labeled autophagosomes colocalize (marked by arrows) with COX IV positive mitochondria in cells overexpressing Bnip3. Images show representative cells overexpressing Bnip3 from two separate experiments. (b) Electron micrographs reveal extensive mitochondrial autophagy in cells overexpressing Bnip3. (c) Co-immunoprecipitation of GFP-LC3 and Bnip3
