Fig. 5.

RecQL4 suppression drastically reduces cell invasiveness in vitro and tumorigenic growth in vivo. (A) RecQL4 suppressed clonal cell lines (C4 and C6) showed reduced cell invasion capacity. (B&C) Suppression of RecQL4 expression in prostate cancer cells reduces tumorigenicity in nude mice. Images of tumors dissected out from the sacrificed mice are shown in B. The tumor size (mm³⁾ versus days of post-injection is shown in C. Difference in relative tumor volume observed at 4 weeks between empty vector and RecQL4 ShRNA transfected cells were found to be statistically significant. *p < 0.01.