Table 5. FA-related lipids significantly altered by alcohol in the heart (n = 10 in each group).
Heart | Ethanol-fed mice | Pair-fed control | |||
---|---|---|---|---|---|
pmol/mg | mean | SD | mean | SD | P |
16:0/18:1 PE | 67.1 | 23.1 | 44.3 | 16.7 | 0.0239 |
16:0/18:2 PE | 69.9 | 35.8 | 30.1 | 5.9 | 0.0029 |
16:0/20:4 PE | 282.4 | 90.2 | 188.2 | 48.7 | 0.0105 |
16:0/22:6 PE | 863.0 | 222.4 | 590.4 | 154.5 | 0.0061 |
18:0/18:2 PE | 198.4 | 105.4 | 88.2 | 28.5 | 0.0054 |
18:0/22:6 PE | 1031.5 | 297.8 | 765.0 | 203.7 | 0.0346 |
22:6 LPE | 34.6 | 6.3 | 26.6 | 5.5 | 0.0092 |
16:0/20:4 PC | 1152.8 | 82.0 | 1053.5 | 113.7 | 0.0454 |
18:0/18:3 PC | 143.7 | 29.9 | 105.2 | 17.8 | 0.0030 |
18:0/18:2 PC | 230.4 | 67.0 | 166.5 | 21.7 | 0.0108 |
18:0/20:4 PC | 1145.1 | 108.9 | 1017.5 | 148.0 | 0.0491 |
16:0/18:0 PC | 130.8 | 4.2 | 142.3 | 13.7 | 0.0276 |
16:0 SM | 216.1 | 44.7 | 264.7 | 53.7 | 0.0481 |
18:1 SM | 19.7 | 3.6 | 25.9 | 6.3 | 0.0196 |
18:0 SM | 179.6 | 16.2 | 210.2 | 36.8 | 0.0343 |
16:0 LPI | 11.1 | 2.0 | 21.7 | 5.5 | 4.7×10E-05 |
18:0 LPI | 119.8 | 23.4 | 167.8 | 41.6 | 0.0073 |
22:5 FA | 79.3 | 26.4 | 170.0 | 52.3 | 0.0002 |
S1P | 0.6 | 0.1 | 0.9 | 0.3 | 0.0198 |
20:0 Cer | 21.3 | 4.7 | 29.6 | 5.0 | 0.0017 |
PE: phosphatidylethanolamine, LPE: lysophosphatidylethanolamine, PC: phosphatidylcholine, SM: sphingomyelin, LPI: lysophosphatidylinositol, FA: fatty acid, S1P: sphingosine-1-phosphate, Cer: ceramide