Skip to main content
. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Nat Neurosci. 2010 Nov 14;13(12):1511–1518. doi: 10.1038/nn.2684

Figure 4. Role of TRPV1 receptors in long-term potentiation at MPP-DGC synapses.

Figure 4

a, Under more physiological recording conditions (i.e. intact NMDAR transmission), a 1 Hz pairing protocol induced robust MPP-LTP, whose magnitude is enhanced in the presence of CPZ (10 µM) or AMG (3 µM) in the bath. Top: Average traces before (black) and after (gray) LTP induction. Bottom: Summary plot showing the enhancement of LTP in the presence of CPZ or AMG. b, LTP is also enhanced in TRPV1−/− mice compared to TRPV1+/+ mice. Number of cells (c) and animals (a) are indicated in parentheses. Summary data consist of mean ± s.e.m.