Table II.
Effect of Acute Hypoxia on Left Ventricular Systolic, Diastolic, and Generated Pressures.
Atria Intact | Atria Removed | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
mmHg | 95% O2 | Acute Hypoxia | 95% O2 | Acute Hypoxia | 95% O2 | Acute Hypoxia | 95% O2 | Acute Hypoxia | 95% O2 | |
Normoxia-adapted rats n=12 | LVSP | 85.2±2.2 | 46.1±2.1* | 81.6±3.9 | 43.6±2.9* | 68.3±6.8 | 47.5±5.9* | 64.7±6.2 | 46.4±6.3* | 70.2±9.0 |
LVDP | 2.5±1.3 | 15.7±2.0* | 3.5±1.2 | 16.8±3.3* | 8.4±3.5 | 22.3±5.1* | 12.8±4.5 | 24.9±6.4* | 18.6±6.9 | |
LVGP | 82.6±2.6 | 30.3±2.4* | 78.3±3.6 | 26.8±2.0* | 59.9±6.8 | 23.3±3.9* | 51.9±6.6 | 21.5±3.1* | 45.2±5.9 | |
Hypoxia-adapted rats n=11 | LVSP | 80.6±5.0 | 49.7±3.1* | 78.8±6.3 | 51.0±5.5* | 69.0±12.2 | 50.4±6.7* | 70.6±11.8 | 55.8±9.7* | 70.3±10.9 |
LVDP | 5.3±1.9 | 18.7±3.5* | 11.0±3.3 | 22.6±4.5* | 16.1±5.7 | 26.7±7.1* | 20.4±7.0 | 30.7±7.4* | 24.0±7.7 | |
LVGP | 76.2±4.1 | 30.3±2.0* | 67.8±5.5 | 28.5±2.9* | 59.1±9.0 | 26.7±2.8* | 55.6±8.1 | 25.6±2.7* | 50.7±7.6 |
Values are mean ± SE. LVSP - left ventricular systolic pressure, LVDP left ventricular diastolic pressure, LVGP left ventricular generated pressure.
P < 0.05. Acute Hypoxia significantly reduced Left Ventricular Systolic, Diastolic, and Generated Pressures compared to normoxia in both normoxia -adapted rats* P < 0.05 (n= 12) and hypoxia-adapted rats* P < 0.05 (n= 11). Of note, removing the atria from the ventricle did not significantly reduce Left Ventricular Systolic, Diastolic, and Generated Pressures