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NQO1 protein levels are undetectable in some AD patient hippocampus. A, NQO1 protein levels in the hippocampus of six examined AD patients are shown and compared with six examined nondemented controls (see “Experimental Procedures”). Immunoblot analysis (IB) was carried out with goat anti-NQO1 and mouse anti-actin and mouse anti-AT8. B, genotype pattern of NQO1 was analyzed by PCR and digestion by HinfI. WT NQO1 and polymorphic C609T plasmids were used as controls.
