Fig. 5. Key regulators of hair formation are downregulated in Msx2–Noggin transgenic mice. Expression of Foxn1, Hoxc13, Msx1 and Lef1 in wild-type and transgenic hair follicles of P12 dorsal skin was analyzed by radioactive section in situ hybridization. Expression of Foxn1, Hoxc13 and Msx1 is strongly reduced in the transgenic hair follicles, while Lef1 mRNA levels are almost normal but extend into the hair shaft (arrowhead). Scale bar: 50 µm.