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Cu2+ and Zn2+ triggered Aβ oligomerization examined by PICUP assay. Photo-induced cross-linked Aβs with and without 25 μm Zn2+, 25 μm Cu2+, 50 μm Fe3+, and 100 μm Al3+ were run on SDS-PAGE. Aside from the dominant monomeric species, in the presence of Cu2+ and Zn2+, trimeric species were induced. The others showed only minor dimer populations.
