FIGURE 2.

Kir2.6 produces small inwardly rectifying potassium currents. A, whole cell currents in COS-1 cells transfected with Kir2.2 or Kir2.6. The currents were elicited by 100-ms pulses applied in 20-mV increments to potentials ranging from −100 to 60 mV from a holding potential of 0 mV. Both Kir2.2 and Kir2.6 form functional channels with characteristic inward rectification. B, whole cell current magnitudes for Kir2.2 and Kir2.6 channels were measured at −100 mV. *, Kir2.6 current amplitude is significantly different compared with Kir2.2 (p < 0.01).