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The TACE inhibitor TAPI-1 prevents TNF-α-induced ERK and RhoA activation. LLC-PK1 cells were treated for 15 min with 10 μm TAPI-1 before the addition of TNF-α or EGF (10 ng/ml, 10 min). pERK (A) or active RhoA (B) levels were detected and quantified as described earlier. In A the maximal effect (EGF-induced pERK) was taken as 100%, as the control (untreated) values in some experiments were too close to the background.
