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Current topological model for TPCs. Schematic summarizing the positions of the numbered residues in human TPCs identified in this study (filled circles). Underlined residues correspond to TPC2. Open circles show the positions of residues identified in previous studies (from left to right): TPC2 Leu-11–12 (23), TPC1 Leu-273 (15), TPC2 Leu-265 (23), TPC2 Asn-257 (21), TPC2 Asn 594, 601 (17), Glu-643 (21). *, numbers refer to amino acid residues of mouse TPC isoforms.
