Crystal structure of rFXIII. One FXIII-A is presented in gray sticks and the other FXIII-A in turquoise ribbons. Residues Asn-436, Asp-438, Ala-457, Glu-485, and Glu-490 form the Ca2+ binding site (red ball and stick, Ca2+ in yellow). Residues Cys-314, His-373, and Asp-396 form the catalytic site (green ball and stick). The structure is from Protein Data Bank entry 1GGU (27).