FIGURE 7.

BH3-M6 sensitizes A549 cells to the proteasome inhibitor CEP-1612 to induce apoptosis. A549 cells were treated with the indicated concentrations of either drug alone or in combination and then processed for various assays as described under “Experimental Procedures.” A, cell viability as measured by MTT assay after 72 h of treatment, error bars indicate standard deviations of triplicates. B, apoptosis as determined by TUNEL assay after 48 h of treatment. C, PARP cleavage after 24 h of drug treatment.