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. 2011 Jan 13;286(11):9174–9184. doi: 10.1074/jbc.M110.166454

FIGURE 5.

FIGURE 5.

Knockdown of β-arr1 and Dyn2 but not Dyn1 prevents Quin-mediated reduction in D2R function in cultured DA neurons. Patch clamp whole-cell recordings of DA neurons in culture transfected with siRNA molecules. A–D, examples of prolonged Quin treatment protocols on recorded DA neurons transfected with Scr, β-arr1-, Dyn1-, or Dyn2-targeting siRNA molecules, respectively. E, comparison between the maximal initial effect of Quin (Quin max, 1–3 min) and the late effects (Quin late, 4–6 min) of this D2R agonist on spontaneous firing rate as a measure of D2R functional desensitization. *, p < 0.05; **, p < 0.01; ***, p < 0.001; two-way ANOVA with Bonferroni multiple comparison tests (n = 16 for Scr, n = 9 for β-arr1, n = 8 for Dyn1, and n = 9 for Dyn2).