Table 3.

Final Parameter Estimates and 95% Confidence Intervals from NONMEM

Parameter	Estimate	Relative SE (%)
Cl (L/h)	25.0	5.96
In subjects receiving only one cycle	17.0	14.6*
V1 (L)	5.68	12.4
Cl2 (L/h)	99.6	15.0
V2 (L) (female)	19.0	11.6
V2 (L) (male)	34.8	15.5*
Cl3 (L/h)	8.76	10.8
V3 (L)	40.4	19.0
Variability in Cl (%CV)	34.8	25.1
Variability in V1 (%CV)	60.6	38.4
Variability in V2 (%CV)	41.5	28.7
RUV (%CV)	17.5	18.3
RUV (SD)	0.0168	35.4

Cl, total body clearance; V apparent volume of distribution; CV, coefficient of variation; RUV residual unexplained variability; relative SE, measure of precision computed by dividing the standard error (SE) by the value of the estimate × 100.

^*Relative SE expressed in terms of the multiplicative term, for the covariate