Table 1.
Demographics and clinical characteristics of subjects with alcohol use disorders (AUDs) and control subjects for test and confirmation cohorts.
| Test Cohort | Confirmation Cohort | |||
|---|---|---|---|---|
| AUD Subjects, n=7 | Control Subjects, n=7 | AUD Subjects, n=7 | Control Subjects, n=7 | |
| Age, mean | 44 ± 6 | 37 ± 11 | 42 ± 9 | 38 ± 12 |
| Gender, no. women/men | 0/7 | 0/7 | 5/2 | 5/2 |
| Tobacco use, % | 5/7 (71%) | 5/7 (71%) | 4/7 (57%) | 4/7 (57%) |
| AUDIT score* | 27 ± 9 | <1 | 26 ± 7 | <1 |
| Days/week consuming alcohol | 5 ± 2 | -- | 6 ± 1 | -- |
| Years consuming alcohol | 30 ± 6 | -- | 25 ± 6 | |
| FEV1, % predicted | 94 ± 9 | 85 ± 7 | 93 ± 11 | 90 ± 12 |
| FVC, % predicted | 97 ± 9 | 93 ± 7 | 96 ± 15 | 93 ± 16 |
| BAL cell count per mL (in millions) | 21 ± 12 | 25 ± 21 | 19 ± 10 | 24 ± 24 |
| Monos/macrophages, % | 91 ± 3 | 93 ± 4 | 91±2 | 96 ± 2 |
| Lymphocytes, % | 6 ± 3 | 6 ± 4 | 7±2 | 3 ± 1 |
| Neutrophils, % | 3 ± 2 | 2 ± 1 | 2±1 | 2 ± 1 |
*
The Alcohol Use Disorders Identification Test (AUDIT) score is calculated from a validated 10 question survey to identify current alcohol use that has been utilized in a variety of clinical settings. AUD was defined as an AUDIT score of ≥8 in men, and ≥5 in women. FEV1=forced expiratory volume in the first second of expiration; FVC=forced vital capacity; BAL=bronchoalveolar lavage.