Figure 1. Expression pattern of neuronal nitric oxide synthase (nNOS) and dystrophin in neuromuscular disorders.

Muscle biopsies of a normal individual (A), a patient with congenital myopathy (C), and a patient with spinal muscular atrophy (E) exhibit normal dystrophin localization at the sarcolemma. In contrast, both patient samples (D and F) demonstrate loss of nNOS at the sarcolemma as compared to a biopsy from a healthy individual (B). Hypertrophic fibers are marked by X. The scale bar is 100 μm.