Fig. 3.

The most effective frequency to induce epileptiform bursts appeared to be 5 Hz. A: examples showing responses in slices from control rats to repetitive stimulations at low (i.e., 1 Hz), medium (5 Hz), and high (10 Hz) frequency. Repetitive stimulation failed to induce epileptiform bursts in nearly all slices from control rats regardless of the frequency of stimulations. B: similar stimulation protocol as in the preceding text, but in slices from rats with kainate-induced epilepsy. Perforant-path repetitive stimulation-induced epileptiform bursts occurred at a range of frequency from 1 to 10 Hz but most often occurred at 5 Hz.