Fig. 5.

Improvement in the goodness of fit between in vivo and in silico firing regimens when varying physiological meaningful general parameters. The improvement in MND in respect to the standard parameters is plotted in color code when varying 8 general parameters individually (see Table 1 for a description of the parameters). Each parameter was varied together with an overall scaling factor applied to all synaptic weights (W_scale), whereas other parameters were held constant. Adjusting some of the parameters considerably improved the fit to in vivo data. For instance, the relative synaptic weights of excitatory to inhibitory neurons needed to be increased dramatically (G). The standard parameter values and the settings showing the best fit in the statistical properties (minimal MND) are indicated with black diamonds and red circles, respectively. The minimal MND values are indicated in the titles. I shows the minimal MND (relative to standard parameters) vs. W_scale for the 8 parameters.