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. Author manuscript; available in PMC: 2011 Mar 16.
Published in final edited form as: Microcirculation. 2009 Jan;16(1):97–111. doi: 10.1080/10739680802279394

Figure 7.

Figure 7

Regression plots for the number of adherent SS RBC/100 :m2 relative to venular diameter in the ex vivo mesocecum treated as follows: (A) PAF alone, (B) PAF and peptide EMD 270179 (cRGDF-ACHA [α-amino cyclohexyl carboxylic acid]), (C) PAF and peptide EMD 66203 (cRGDFV), (D) PAF and control peptide EMD 135981 (cRβ-ADFV). The regression lines represent the multiplicative equation of the form Y = aX-b for the best fit. In preparations treated PAF alone, adhesion of SS RBCs showed a strong correlation with the venular diameter. Preparations treated with αVβ3 antagonist EMD 270179 or EMD 66203 showed a marked inhibition of SS RBC adhesion in venules of all diameters, with EMD 66203 having a greater inhibitory effect, especially in small-diameter venules, the site of frequent blockage. In contrast, in the presence of the control peptide EMD 135981, the resulting adhesion was essentially similar to that observed with PAF alone. Modified from Finnegan et al. (22).