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. Author manuscript; available in PMC: 2011 Dec 15.
Published in final edited form as: Cancer Res. 2010 Dec 15;70(24):10310–10320. doi: 10.1158/0008-5472.CAN-10-2062

Figure 2. MLN4924 induces re-replication through inhibition of CRL4Cdt2.

Figure 2

(A) HCT116 cells were tranfected with GL2, Cdt2, Geminin siRNA and treated with MLN4924 as described in Fig. 1(A). Cell lysates were harvested and blotted with indicated antibodies. (B) DNA contents of the cells treated in (A) were determined using FACS and plotted in horizontal bar graph. Representative FACS data from siGL2 treated cells indicating different DNA contents measured.