Table 4.
Clinical data of subjects with lithium + olanzapine treatment
| Assessment | Clinical visit | ||
|---|---|---|---|
| Week 0 Mean (SD) | Week 4 Mean (SD) | Week 8 Mean (SD) | |
| Subjects, n | 20 | 20 | 13 |
| Lithium, mg/d | 525.00 (111.80) | 987.50 (221.76) | 980.80 (189.89) |
| Serum lithium level, mEq/L | – | 0.71 (0.16) | 0.62 (0.10) |
| Olanzapine, mg/d | 7.63 (3.86) | 12.63 (5.56) | 7.00 (3.50) |
| YMRS score | 28.50 (4.15) | 3.35 (5.55) | 1.43 (4.80) |
| CGI-S score | 5.25 (0.64) | 1.65 (0.93) | 1.21 (0.58) |
| HAM-D score | 2.40 (2.46) | 0.50 (0.95) | 0.43 (0.85) |
| MADRS score | 4.25 (2.05) | 0.45 (1.05) | 0.71 (1.27) |
| Weight (kg) | 59.50 (11.64) | 60.89 (11.87) | 59.75 (10.72) |
| Heart rate (bpm) | 81.00 (7.47) | 80.32 (5.63) | 78.00 (6.38) |
| Systolic blood pressure (mmHg) | 115.75 (10.92) | 111.67 (12.60) | 113.33 (11.55) |
| Diastolic blood pressure (mmHg) | 78.00 (7.15) | 70.83 (5.49) | 72.50 (7.83) |
| Blood glucose (mmol/L) | 4.79 (0.71) | 4.79 (0.69) | 5.12 (0.44) |
| Cholesterol (mmol/L) | 4.13 (1.01) | 4.64 (1.04) | 4.72 (1.29) |
| Triglycerides (mmol/L) | 1.17 (0.81) | 1.64 (0.95) | 1.91 (0.57) |
| Alanine aminotransferase (U/L) | 20.70 (10.39) | 43.04 (20.41) | 33.10 (22.22) |
| Aspartate aminotransferase (U/L) | 29.70 (18.41) | 34.45 (19.79) | 25.30 (10.74) |
YMRS = Young Mania Rating Scale; CGI-S = Clinical Global Impression for Bipolar Disorder-Severity; HAM-D = Hamilton Depression Rating Scale; MADRS = Montgomery-Åsberg Depression Rating Scale.