Table 2.
Results of the applications of trioFS to the 100 data sets from each of 8 simulation scenarios in which the interaction S3D ⋀ S7D is intended to be disease-associated. This tables contains the numbers of applications in which this interaction is found, is identified as the most important interaction or amongst the five most important interactions, respectively, the numbers of applications in which an extension of S3D ⋀ S7D is identified as most important interaction or amongst the five most important interactions, respectively, and the numbers of applications in which S3D ⋀ S7D shows a Bonferroni corrected p-value p smaller than 0.05 or equal to zero, and an extensions exhibits a p-value pExt smaller than 0.05, using VIMAdj or, in brackets, VIMTrio as importance measure
| OR = 1.5 | OR = 2.0 | OR = 2.5 | OR = 3.0 | |||||
|---|---|---|---|---|---|---|---|---|
| Trios | 500 | 1000 | 500 | 1000 | 500 | 1000 | 500 | 1000 |
| Found | 8 | 33 | 87 | 100 | 99 | 100 | 100 | 100 |
| Top 1 | 0 (0) | 0 (0) | 44 (20) | 97 (72) | 99 (75) | 100 (96) | 97 (91) | 100 (99) |
| Top 5 | 1 (1) | 0 (0) | 54 (37) | 100 (89) | 99 (87) | 100 (98) | 100 (100) | 100 (100) |
| Ext. Top 1 | 0 (0) | 0 (0) | 13 (20) | 0 (22) | 1 (24) | 0 (4) | 1 (7) | 0 (1) |
| Ext. Top 5 | 1 (1) | 1 (1) | 67 (67) | 98 (98) | 98 (98) | 99 (99) | 100 (100) | 99 (99) |
| p ≤ 0.05 | 0 (0) | 0 (0) | 0 (0) | 67 (60) | 59 (64) | 100 (99) | 99 (96) | 100 (100) |
| p = 0 | 0 (0) | 0 (0) | 0 (0) | 46 (36) | 32 (37) | 100 (99) | 94 (92) | 100 (99) |
| pExt ≤ 0.05 | 0 (0) | 0 (0) | 0 (0) | 7 (7) | 1 (1) | 61 (72) | 18 (47) | 90 (97) |