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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Ann Neurol. 2011 Feb;69(2):303–311. doi: 10.1002/ana.22297

Figure 3. Patients’ antibodies react with wild-type but not Caspr2-null mouse brains.

Figure 3

The CSF (A) and serum (B) from 2 different patients with Caspr2 antibodies immunostain the hippocampus of a wild-type mouse in a pattern identical to that obtained with a rabbit polyclonal antibody against Caspr2 (C). This staining is not seen in sections from a Caspr2-null mouse (A–C, columns on the right). The pattern of staining with a CSF from a patient with limbic encephalitis associated with LGI1 antibodies is subtly different from Caspr2 and it is not affected using wild-type or Caspr2-null mice (D). The CSF of a control individual without Caspr2 or LGI1 antibodies does not label either sample (E). Scale bar: 100 μm