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. 2011 Mar 3;2:4. doi: 10.1186/1759-8753-2-4

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Copyright ©2011 Neumann et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Graphical representation of the conserved portion of the integrase protein sequence. Integrase sequences extracted from CRM, Tekay, Reina and Galadriel chromoviruses aligned using the Muscle program are shown as sequence logo plots [96]. CRM clade members are shown in the upper part of the figure, and those from the other clades are shown in the lower part. Despite the overall high level of sequence similarity, several amino acid residues are conserved only within the CRM clade. The HHCC and DD35E motifs are indicated by green and red stars, respectively.