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Sequence motifs surrounding the axial ligands. (A) Sequence logo from 32 heme c proteins with histidine as axial ligand shows the classic CXXCH heme c binding motif; (B) Sequence logo from 18 heme b proteins with cysteine as axial ligand. The sequence logos were created with WebLogo [74]; (C) Arginine-334 (red sticks) of 1N97A interacts with heme propionates (red spheres); and (D) Interactions between histidine-353 (red sticks) of 1GWIA and heme propionate groups (red spheres).
