Table 3.
Association between aberrant DNA methylation and the prognosis of ESCC
| Characteristics | Total patients | Death, N(%) | HR(95% CI)† | P |
|---|---|---|---|---|
| Cancer tissue | ||||
| P16 | ||||
| Unmethylated | 14 | 8(57.14) | 1 | |
| Methylated | 106 | 50(47.17) | 0.67(0.32-1.41) | 0.288 |
| MGMT | ||||
| Unmethylated | 88 | 43(48.86) | 1 | |
| Methylated | 32 | 15(46.88) | 1.00(0.55-1.79) | 0.989 |
| hMLH1 | ||||
| Unmethylated | 116 | 56(48.28) | 1 | |
| Methylated | 4 | 2(50.00) | 1.16(0.28-4.76) | 0.836 |
| Any gene | ||||
| Unmethylated | 11 | 5(45.45) | 1 | |
| Methylated | 109 | 53(48.62) | 1.07(0.43-2.69) | 0.880 |
| Remote normal appearing tissue | ||||
| P16 | ||||
| Unmethylated | 74 | 36(48.65) | 1 | |
| Methylated | 46 | 22(47.83) | 1.02(0.60-1.74) | 0.937 |
| MGMT | ||||
| Unmethylated | 107 | 51(47.66) | 1 | |
| Methylated | 13 | 7(53.85) | 1.35(0.61-2.97) | 0.461 |
| hMLH1 | ||||
| Unmethylated | 120 | 58(48.33) | - | - |
| Methylated | 0 | - | - | - |
| Any gene | ||||
| Unmethylated | 67 | 32(47.76) | 1 | |
| Methylated | 53 | 26(49.06) | 1.13(0.67-1.89) | 0.655 |
| MTHFR C677T | ||||
| CC | 35 | 16(45.71) | 1 | |
| CT | 54 | 28(51.85) | 1.15(0.62-2.13) | 0.653 |
| TT | 31 | 14(45.16) | 0.98(0.48-2.02) | 0.964 |
| CT+TT | 85 | 42(49.41) | 1.09(0.61-1.94) | 0.770 |
†: HR(95% CI), hazard ratio (95% confidence interval)