Table 1.

Structural information for the observed and/or reported lumefantrine related impurities

#	Compound [formula, mono-isotopic mass]	Structure	Origin
1	Desbenzylketo N-oxide [C23H27NO3Cl2, MW 435.14]		Alkaline stress Oxidative stress
2	Lumefantrine (mono-)desbutyl derivative [C26H24NOCl3, MW 473.09]		Oxidative stress Metabolite
3	Lumefantrine N-oxide [C30H32NO2Cl3, MW 543.15]		Oxidative stress Degradation
4	2,7-dichloro-4-[2-(di-n-butylamino)-1-hydroxyethyl]-9H-fluoren-9-one; Desbenzylketo derivative (DBK) [C23H27NO2Cl2, MW 419.14]		Oxidative stress Acidic stress Degradation
5	2-(di-n-butylamino)-1-[2,7-dichloro-9H-fluoren-4-yl]ethanol; Desbenzyl derivative [C23H29NOCl2, 405.16]		Synthesis
6	Synthesis impurity found in lumefantrine API; Lumefantrine oxide [C30H32NO2Cl3, MW 543.14]		Synthesis
7	Synthesis impurity found in lumefantrine API; Lumefantrine oxide [C30H32NO2Cl3, MW 543.14]		Synthesis
8	(RS,Z)-2-(Dibutylamino)-2-(2,7-dichloro-9-(4-chloro-benzylidene)-9H-fluoren-4-yl)ethanol (isomeric compound); Impurity A (Ph. Int./USP Salmous) [C30H32NOCl3, MW 527.15]		Synthesis
9	Synthesis impurity found in lumefantrine API; Lumefantrine oxide [C30H32NO2Cl3, MW 543.14]		Synthesis
10	(1S,3R,5R)-1,3-bis((EZ)-2,7-Dichloro-9-(4-chlorobenzyl-idene)-9H-fluoren-4-yl)-2,6-dioxabicyclo[3.1.0]hexane; Impurity BA (USP Salmous) [C44H24Cl6O2, 797.39]		Synthesis
11	2-((EZ)-2,6-Dichloro-9- (4-chlorobenzylidene)-9H-fluoren-4-yl)-3'-((EZ)-2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl)-2,2'-bioxirane; Impurity BB (USP Salmous) [C44H24Cl6O2, 797.39]		Synthesis