Table 3.
HPLC characteristics of lumefantrine related impurities
| # | Compound | RT(1) | RRT(2) | Most abundant m/z observed |
|---|---|---|---|---|
| 1 | Desbenzylketo N-oxide | 1.79 | 0.08 | 436.14 |
| 2 | Monodesbutyl derivative | 3.25 | 0.15 | 474.00 |
| 3 | Lumefantrine N-oxide | 3.96 | 0.17 | 544.08 |
| 4 | Desbenzylketo derivative | 7.41 | 0.33 | 420.13 |
| 5 | Desbenzyl derivative | 7.69 | 0.34 | 406.09 |
| 6 | Lumefantrine oxide | 10.96 | 0.49 | 544.12 |
| 7 | Lumefantrine oxide | 11.45 | 0.52 | 544.12 |
| 8 | Impurity A | 12.70 | 0.58 | 528.10 |
| 9 | Lumefantrine oxide | 12.97 | 0.59 | 544.12 |
| L | Lumefantrine | 22.28 | 1.00 | 528.10 |
(1) Retention time (min.)
(2) Relative retention time