Table 2.
Toxicity | Number of Patients Exhibiting Toxicity Per Dose Level | Total Pts. (%) |
||||||||
---|---|---|---|---|---|---|---|---|---|---|
Type | Grade | 1 mg/hr |
2 mg/hr |
4 mg/hr |
8 mg/hr |
12 mg/hr |
18 mg/hr |
27 mg/hr |
40 mg/hr |
|
Anorexia | 1 | 1 | 2 (6) | |||||||
2 | 1 | |||||||||
Constipation | 1 | 1 | 1 (3) | |||||||
Diarrhea | 1 | 1 | 1 | 2 (6) | ||||||
Fatigue | 1 | 1 | 2 | 6 (17) | ||||||
2 | 2 | 1 | ||||||||
Fingernail changes |
1 | 1 | 1 (3) | |||||||
Mucositis | 1 | 1 | 1 (3) | |||||||
Insomnia | 1 | 1 | 1 (3) | |||||||
Nausea | 1 | 1 | 1 | 1 | 3 (9) | |||||
Pain | 1 | 1 | 1 (3) |