Table 2.
Incidence and Severity of Cycle 1 Toxicities Considered At Least Possibly Related to Study Drug, for All Patients (Pts)
| Toxicity | Number of Patients Exhibiting Toxicity Per Dose Level | Total Pts. (%) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Type | Grade | 1 mg/hr |
2 mg/hr |
4 mg/hr |
8 mg/hr |
12 mg/hr |
18 mg/hr |
27 mg/hr |
40 mg/hr |
|
| Anorexia | 1 | 1 | 2 (6) | |||||||
| 2 | 1 | |||||||||
| Constipation | 1 | 1 | 1 (3) | |||||||
| Diarrhea | 1 | 1 | 1 | 2 (6) | ||||||
| Fatigue | 1 | 1 | 2 | 6 (17) | ||||||
| 2 | 2 | 1 | ||||||||
| Fingernail changes |
1 | 1 | 1 (3) | |||||||
| Mucositis | 1 | 1 | 1 (3) | |||||||
| Insomnia | 1 | 1 | 1 (3) | |||||||
| Nausea | 1 | 1 | 1 | 1 | 3 (9) | |||||
| Pain | 1 | 1 | 1 (3) | |||||||