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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Mol Genet Metab. 2010 Dec 31;102(4):436–447. doi: 10.1016/j.ymgme.2010.12.014

Figure 4. α-Synuclein aggregates in brain.

Figure 4

Brain sections from 12-wk WT, PS-NA, 4L/PS-NA, and 9H/PS-NA mice were processed for immunofluorescence analyses with anti α-synuclein antibody conjugated with Alexa-610 (red). Images were taken from cerebrum (Cr) and hippocampus (Hp) using the same exposure condition. Fine 1-2 μm α-synuclein particles were present in each genotype of mouse brain. α-Synuclein aggregates (≥ 5 μm) were only observed in the cerebrum of 12-wk 4L/PS-NA and 9H/PS-NA mice (arrows) or the hippocampus of 12-wk 9H/PS-NA mice (arrows). Such aggregates were not seen in WT brains. Neuronal cell nuclei were stained by DAPI (blue). The scale bars are 20 μm.