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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Circ Heart Fail. 2011 Jan 7;4(2):214–223. doi: 10.1161/CIRCHEARTFAILURE.110.958694

Figure 1. JPH2 expression is decreased in humans with hypertrophic cardiomyopathy.

Figure 1

A. Representative Western blot of JPH2 expression levels in lysates prepared from left ventricular myocardium obtained from three healthy traumatic death victims and myectomy tissue from 11 patients with HCM genotype-positive for mutations in MYH7 (N = 5 individuals), MYBPC3 (3) or genotype-negative (3). From left to right, HCM patients hosted mutations of MYH7-G741R, -R663H, -I736T, -R403Q, -M922K and MYBPC-E258K, -L527 fs/3, and -1258 fs/71, respectively. GAPDH served as a loading control. B. Graph of relative mean band density of JPH2 expression of individuals with HCM (mean of 8 blots per individual) relative to control specimens (mean of 5 blots per individual). ‡, P < 0.05 versus each of the trauma samples; †, P < 0.05 versus two of the three trauma samples. Inset) Graph of the mean Western blot band density of all HCM specimens relative to mean control tissue band density. ***, P < 0.0001.

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