Table 1.
Relationship of demographic, treatment, and tumor characteristics to the risk of dying
| Alive (n=1193) | BC-related (n=283) | Non-BC related (n=435) | BC-related death | All-cause death | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | HR1 | 95% CI | HR1 | 95% CI | |
| Age at diagnosis2 | ||||||||||
| 45-54 | 109 | (9.1) | 31 | (11.0) | 7 | (1.6) | 1.00 | (ref) | 1.00 | (ref) |
| 55-64 | 417 | (35.0) | 93 | (32.9) | 69 | (15.9) | 0.76 | (0.50-1.14) | 1.07 | (0.75-1.52) |
| 65-74 | 532 | (44.6) | 123 | (43.5) | 236 | (54.3) | 1.02 | (0.60-1.74) | 2.04 | (1.35-3.08) |
| 75-79 | 135 | (11.3) | 36 | (12.7) | 123 | (28.3) | 1.14 | (0.58-2.22) | 3.38 | (2.13-5.35) |
| Age at menopause | ||||||||||
| <45 | 250 | (22.5) | 70 | (26.3) | 115 | (29.2) | 1.00 | (ref) | 1.00 | (ref) |
| 45-49 | 356 | (32.0) | 84 | (31.6) | 115 | (29.2) | 1.02 | (0.73-1.42) | 0.89 | (0.73-1.10) |
| 50+ | 507 | (45.6) | 112 | (42.1) | 164 | (41.6) | 0.97 | (0.71-1.32) | 0.79 | (0.66-0.96) |
| Missing | 80 | 17 | 41 | |||||||
| Family history | ||||||||||
| No 1st degree | 868 | (77.7) | 199 | (76.8) | 322 | (78.3) | 1.00 | (ref) | 1.00 | (ref) |
| 1st degree | 249 | (22.3) | 60 | (23.2) | 89 | (21.7) | 1.08 | (0.80-1.45) | 1.04 | (0.86-1.26) |
| Missing | 76 | 24 | 24 | |||||||
| Mammography3,4 | ||||||||||
| No | 110 | (9.5) | 68 | (24.9) | 77 | (18.4) | 1.00 | (ref) | 1.00 | (ref) |
| Yes | 1054 | (90.5) | 205 | (75.1) | 341 | (81.6) | 0.42 | (0.32-0.56) | 0.50 | (0.42-0.60) |
| Missing | 29 | 10 | 17 | |||||||
| Time since last mammogram4 | ||||||||||
| None | 59 | (5.1) | 48 | (17.5) | 48 | (11.3) | 1.00 | (ref) | 1.00 | (ref) |
| <2 yrs | 845 | (72.3) | 142 | (51.6) | 268 | (63.1) | 0.30 | (0.22-0.42) | 0.44 | (0.35-0.55) |
| 2 yrs | 157 | (13.4) | 42 | (15.3) | 53 | (12.5) | 0.45 | (0.30-0.68) | 0.51 | (0.38-0.67) |
| 3+ yrs | 107 | (9.2) | 43 | (15.6) | 56 | (13.2) | 0.59 | (0.39-0.90) | 0.73 | (0.55-0.96) |
| Missing | 25 | 8 | 10 | |||||||
| Stage | ||||||||||
| Local | 950 | (79.9) | 95 | (34.1) | 331 | (77.3) | 1.00 | (ref) | 1.00 | (ref) |
| Regional/Distant | 239 | (20.1) | 184 | (65.9) | 97 | (22.7) | 5.69 | (4.41-7.35) | 2.23 | (1.91-2.61) |
| Missing | 4 | 4 | 7 | |||||||
| Histology | ||||||||||
| Ductal | 830 | (69.6) | 196 | (69.3) | 290 | (66.7) | 1.00 | (ref) | 1.00 | (ref) |
| Any Lobular5 | 200 | (16.8) | 60 | (21.2) | 87 | (20.0) | 1.21 | (0.90-1.63) | 1.10 | (0.91-1.33) |
| Other | 163 | (13.7) | 27 | (9.5) | 58 | (13.3) | 0.72 | (0.48-1.10) | 0.94 | (0.74-1.19) |
| ER status | ||||||||||
| ER+ | 995 | (83.4) | 208 | (73.5) | 371 | (85.3) | 1.00 | (ref) | 1.00 | (ref) |
| ER- | 132 | (11.1) | 61 | (21.6) | 49 | (11.3) | 2.09 | (1.55-2.82) | 1.70 | (1.38-2.10) |
| Borderline/Unknown | 66 | (5.5) | 14 | (4.9) | 15 | (3.4) | 1.10 | (0.64-1.89) | 0.87 | (0.59-1.27) |
| PR status | ||||||||||
| PR+ | 904 | (75.8) | 175 | (61.8) | 322 | (74.0) | 1.00 | (ref) | 1.00 | (ref) |
| PR- | 226 | (18.9) | 94 | (33.2) | 98 | (22.5) | 1.91 | (1.48-2.48) | 1.58 | (1.33-1.88) |
| Borderline/Unknown | 63 | (5.3) | 14 | (4.9) | 15 | (3.4) | 1.24 | (0.72-2.15) | 0.93 | (0.63-1.37) |
| Grade | ||||||||||
| Well | 248 | (23.7) | 15 | (6.2) | 83 | (21.8) | 1.00 | (ref) | 1.00 | (ref) |
| Moderate | 446 | (42.6) | 72 | (29.6) | 158 | (41.6) | 2.35 | (1.35-4.11) | 1.25 | (0.98-1.59) |
| Poor | 302 | (28.8) | 129 | (53.1) | 121 | (31.8) | 5.42 | (3.16-9.31) | 1.98 | (1.56-2.52) |
| Undifferentiated | 51 | (4.9) | 27 | (11.1) | 18 | (4.7) | 6.49 | (3.41-12.34) | 2.10 | (1.46-3.02) |
| Missing | 146 | 40 | 55 | |||||||
| Tumor size | ||||||||||
| <1 cm | 330 | (28.2) | 21 | (8.3) | 112 | (26.5) | 1.00 | (ref) | 1.00 | (ref) |
| 1-<2 cm | 545 | (46.6) | 55 | (21.7) | 180 | (42.6) | 1.47 | (0.88-2.44) | 1.09 | (0.88-1.35) |
| 2+ cm | 294 | (25.1) | 178 | (70.1) | 131 | (31.0) | 7.17 | (4.54-11.31) | 2.19 | (1.78-2.69) |
| Missing | 24 | 29 | 12 | |||||||
1
Models adjusted for age (continuous), study, and mammography history, except where noted
2
Models not adjusted for age
3
History of mammography in the 5 years prior to diagnosis
4
Models not adjusted for mammography history
5
Lobular includes mixed lobular