TABLE 1.

Biodistribution results for ¹¹¹In-DOTA-HSA-Z_HER2:342 in nude mice bearing subcutaneously xeno-transplanted SKOV3 human ovarian cancer. Data are expressed as the percentage administered activity (injected dose) per gram of tissue (% ID/g) after intravenous injection of the probe at 1, 4, 24 and 48 h (n = 3). For 4 h-block, mice were co-injected with the radioactive probe and 300 μg of Ac-Cys-Z_HER2:342.

Site	1 h	4 h	4h - block	24 h	48 h
Blood	25.95 ± 3.54	20.11 ± 3.5	19.43 ± 1.51	5.15 ± 0.68	3.02 ± 0.87
Tumor	4.61 ± 0.46	12.52 ± 1.13*	6.49 ± 0.59	16.26 ± 1.33	16.73 ± 1.16
Heart	9.05 ± 3.13	8.18 ± 0.90	7.88 ± 0.37	2.19 ± 1.5	3.37 ± 0.5
Liver	11.79 ± 2.89	15.56 ± 1.84	18.41 ± 1.53	14.11 ± 2.61	13.56 ± 2.94
Lungs	11.54 ± 3.37	11.64 ± 2.68	10.68 ± 0.92	3.5 ± 0.46	2.56 ± 0.61
Muscle	1.09 ± 0.67	1.14 ± 0.19	1.67 ± 0.48	1.15 ± 0.54	1.04 ± 0.27
Spleen	7.66 ±1.5	10.24 ± 0.42	9.69 ± 0.61	7.08 ± 0.68	8.71 ± 1.12
Skin	1.86 ± 0.89	4.11 ± 1.65	3.99 ± 1.19	5.99 ± 0.06	5.2 ± 0.73
Bone	3.58 ± 0.72	3.49 ± 1.27	2.99 ± 0.22	2.9 ± 0.28	3.33 ± 0.05
Kidneys	11.5 ± 2.05	9.95 ± 0.67*	8.11 ± 0.16	6.06 ± 0.69	5.73 ± 0.88
Intestine	3.9 ± 0.31	3.57 ± 0.46	3.94 ± 0.83	1.85 ± 0.41	1.94 ± 0.14
Stomach	2.47 ± 0.29	2.79 ± 0.67	2.35 ± 0.54	1.53 ± 0.21	1.28 ± 0.1
Brain	0.92 ± 0.26	0.55 ± 0.07	0.56 ± 0.16	0.18 ± 0.05	0.12 ± 0.03
Pancreas	2.38 ± 0.46	1.90 ± 0.14	1.71 ± 0.11	1.28 ± 0.34	1.61 ± 0.59
Tumor /Blood ratio	0.15 ± 0.06	0.64 ± 0.12*	0.33 ± 0.03	3.18 ± 0.40	5.9 ± 2.01
Tumor /Muscle ratio	4.09 ± 2.52	11.12 ± 1.08*	4.2 ± 1.6	15.82 ± 5.41	16.89 ± 4.67

^*P < 0.05, compared with 4 h.