Table 3.

Population-Differentiated Novel Insertions

Locusa	Max VST (Initial)b	Max VST (Follow-up)	Copy-Number Difference Observed	Conserved Elementsc	Position Relative to Nearest Gened
novel-locus_857	0.82	0.82	European > African
OEA_200333	0.79	0.66	Non-Asian > Asian
novel-locus_280	0.78	0.78	African > Non-African	no	578 kb upstream of BTBD3
novel-locus_156	0.74	0.72	African > Asian
novel-locus_506	0.70	0.79	African > Non-African
OEA_206812	0.63	0.72	African > Non-African
novel-locus_1132	0.57	0.58	European > Non-European
novel-locus_585	0.55	0.70	African > Non-African
novel-locus_335	0.53	0.53	Non-European > European	yes	17.5 kb downstream of ATP6V1G3
novel-locus_399	0.53	0.53	African > Non-African
novel-locus_158	0.52	0.58	YRI+LWK > European	no	Intron of ACTR3
novel-locus_371	0.51	0.66	Non-European > European	no	Intron of PLEK2
OEA_207712	0.50	0.63	European > African
novel-locus_976	0.50	0.50	Non-Asian > Asian
novel-locus_687	0.49	0.51	Non-European > European	yes	Intron of LCT
OEA_209873	0.49	0.63	African > Asian
OEA_200783	0.49	0.67	African > Non-African
novel-locus_955	0.48	0.36	African > Non-African	yes	Intron of TBCE
novel-locus_1181	0.47	0.47	African > Asian
OEA_204853	0.46	0.52	African > Non-African
novel-locus_707	0.44	0.40	African > Non-African	no	1.8 Mb downstream of NCAM2
OEA_201275	0.44	0.37	African > Asian
novel-locus_153	0.43	0.41	Non-Asian > Asian
OEA_202951	0.43	0.55	European > Non-European
novel-locus_981	0.43	0.43	African > Non-African
OEA_209724	0.42	0.53	African > Non-African
novel-locus_168	0.42	0.56	African > Asian	no	321 bp downstream of SNORD114-6
novel-locus_247	0.41	0.41	Asian > Non-Asian	yes	36 kb upstream of CHORDC1
novel-locus_297	0.41	0.47	African > European	yes	2 kb downstream of GSDMC
novel-locus_90	0.41	0.41	African > European
novel-locus_1164	0.41	0.37	African > Non-African
novel-locus_1042	0.40	0.46	African > Non-African	no	18 kb upstream of GPR39
OEA_206891	0.40	0.50	African > Non-African

^aLocus names are from Kidd et al.¹⁸ One-end anchored sequences are given the designation “OEA_” (see Table S3 for full clone names).

^bPopulation-differentiated novel insertions with maximum V_ST values of at least 0.4 are shown.

^cThe presence of conserved elements was tested in Kidd et al.¹⁸ and is given for insertions with breakpoint sequence data.

^dPositions relative to genes, along with breakpoint sequence data and precise genomic locations, are given for insertions (Table S2).