Table 1.

Simulation Results: Estimated Heritability on the Liability Scale and Empirical Standard Error over Replicates

Prevalence of Disease in the Population (K)	Heritability of Liability
	0.1	0.3	0.5	0.7	0.9
K = 0.5	0.09 (0.006)	0.28 (0.010)	0.51 (0.013)	0.70 (0.016)	0.90 (0.016)
K = 0.2	0.10 (0.007)	0.31 (0.009)	0.49 (0.011)	0.71 (0.012)	0.91 (0.013)
K = 0.1	0.11 (0.007)	0.30 (0.009)	0.49 (0.009)	0.71 (0.012)	0.89 (0.012)
K = 0.01	0.11 (0.009)	0.30 (0.011)	0.49 (0.012)	0.70 (0.013)	0.90 (0.012)
K = 0.001	0.17 (0.020)	0.31 (0.020)	0.56 (0.021)	0.75 (0.021)	0.94 (0.022)

In all examples the proportion of cases in the case-control sample was p = 0.5. Sample size was 10,000 (5000 cases, 5000 controls) for all situations. The number of replicates was 100.