Figure 1.

Association Results for the GWAS and the Two Best-Supported Genes from the Follow-Up Study

(A) Manhattan plot.

(B) Regional association plots (RAPs) displaying NCAN and MAD1L1. The most associated marker from the GWAS (enlarged red diamond) is centered in a genomic window of 1 Mb (hg18, RefSeq genes); its p value from the combined analysis (meta) is shown (enlarged blue diamond). The LD strength (r²) between the sentinel SNP from the GWAS and its flanking markers is demonstrated by the red (high) to white (low) color bar. The recombination rate (cM/Mb; second y axis) is plotted in blue, according to HapMap-CEU. RAPs were generated with SNAP.⁴²