Table 1.
Descriptive Data for Patients with Bipolar Disorder and Controls Following Quality Control
| Sample | Ancestry | N Patients | N Controls | BD1 (%) | BD2 (%) | SAB (%) | BD-NOS (%) | MaD (%) | Diagnosis | Interview | Controls Screened? |
|---|---|---|---|---|---|---|---|---|---|---|---|
| GWAS | |||||||||||
| Germany I | German | 682 | 1300 | 679 (99.56) | 2 (0.29) | 1 (0.15) | 0 | 0 | DSM-IV | SADS-L, SCID | no |
| Replication I | |||||||||||
| Germany II | German | 361 | 755 | 138 (38.23) | 93 (25.76) | 130 (36.01) | 0 | 0 | DSM-IV | SADS-L, SCID | no |
| Poland | Polish | 411 | 504 | 323 (78.59) | 88 (21.41) | 0 | 0 | 0 | DSM-IV | SCID | no |
| Spain | Spanish | 297 | 391 | 290 (97.64) | 7 (2.36) | 0 | 0 | 0 | DSM-IV | SADS-L | no |
| Russia | Russian | 326 | 329 | 324 (96.38) | 2 (0.61) | 0 | 0 | 0 | DSM-IV | SCID | no |
| Romania | Romanian | 227 | 221 | 227 (100) | 0 | 0 | 0 | 0 | DSM-IV | SCID | yes |
| Bosnia and Herzegovina / Serbia | Bosnian / Serbian | 107 | 113 | 107 (100) | 0 | 0 | 0 | 0 | DSM-IV | SCID | no |
| Total | 2411 | 3613 | 2088 | 192 | 131 | 0 | 0 | ||||
| Replication II | |||||||||||
| GAIN-EA / TGEN1 | European | 2189 | 1434 | 2062 (94.20) | 0 | 127 (5.80) | 0 | 0 | DSM-III, DSM-IV, RDC |
DIGS | yes |
| WTCCC-BD / Exp. Ref. Grp. | British | 1868 | 14,311 | 1594 (85.33) | 134 (7.17) | 98 (5.25) | 38 (2.03) | 4 (0.21) | RDC | SCAN | no |
| Germany III | German | 497 | 857 | 376 (75.65) | 88 (17.71) | 2 (0.04) | 31 (6.24) | 0 | DSM-IV | AMDP, CID-S, SADS-L, SCID | yes |
| France | French | 471 | 1758 | 360 (76.43) | 99 (21.02) | 0 | 12 (2.55) | 0 | DSM-IV | DIGS | no |
| Iceland | Icelandic | 422 | 11,487 | 323 (76.54) | 72 (17.06) | 0 | 27 (6.40) | 0 | DSM-III, DSM-IV, ICD10, RDC |
CID-I, SADS-L | no |
| Australia | European | 380 | 1530 | 291 (76.58) | 87 (22.89) | 1 (0.26) | 1 (0.26) | 0 | DSM-IV | DIGS, FIGS, SCID | no |
| Norway | Norwegian | 203 | 372 | 128 (63.05) | 65 (32.02) | 0 | 10 (4.93) | 0 | DSM-IV | SCID, PRIME-MD | yes |
| Total | 6030 | 31,749 | 5134 | 545 | 228 | 119 | 4 | ||||
| Grand Total | 8441 | 35,362 | 7222 | 737 | 359 | 119 | 4 | ||||
Patients received diagnoses according to the indicated diagnostic criteria and interviews. Protocols and procedures were approved by the local Ethics Committees. Written informed consent was obtained from all patients and controls. Ancestry was assigned to patients and controls on the basis of self-reported ancestry. The samples from Bosnia and Herzegovina / Serbia were merged due to the small number of subjects. The Expanded Reference Group for the WTCCC-BD sample comprised the 1958 British Birth Cohort controls, the UK Blood Services controls supplemented by the other 6 disease sets (coronary artery disease, Crohn's disease, hypertension, rheumatoid arthritis, type 1 and type 2 diabetes) as defined by the WTCCC (2007).1
The following abbreviations are used: AMDP, Association for Methodology and Documentation in Psychiatry;31 BD1, bipolar disorder type 1; BD2, bipolar disorder type 2; BD-NOS, bipolar disorder not otherwise specified; CID-I, Composite International Diagnostic Interview;32,33 CID-S, Composite International Diagnostic Screener;34 DIGS, Diagnostic Interview for Genetic Studies;35 DSM-III / DSM-IV, Diagnostic and Statistical Manual of Mental Disorders;9 Exp. Ref. Grp., Expanded Reference Group (11,373 controls);1 FIGS, Family Interview for Genetic Studies;36 GAIN-EA, BD sample with European ancestry from the Genetic Association Information Network (1001 patients and 1033 controls);6 ICD10, International Statistical Classification of Diseases and Related Health Problems;37 MaD, Manic disorder according to RDC; N, number of subjects; PRIME-MD, Primary Care Evaluation of Mental Disorders;38 RDC, Research Diagnostic Criteria;39 SAB, schizoaffective disorder (bipolar type); SADS-L, Schedule for Affective Disorders and Schizophrenia;40 SCAN, Schedules for Clinical Assessment in Neuropsychiatry;41 SCID, Structured Clinical Interview for DSM disorders;11 TGEN1, Translational Genomics Research Institute (genotyping wave 1 with 1190 patients and 401 controls).