Figure 11.

Expression of Gadd45-related genes. (A) Weak expression of Gadd45γ in the animal cap ectoderm of the blastula [Side view]. (B) Gadd45α is diffusely expressed in the ectoderm and non-involuted mesoderm of the gastrula [Side view]. (C) and (D) Gadd45α is expressed throughout the neural plate, PPE and cement gland [C, Anterior view; D, Dorsal view]. At neural tube closure, Gadd45α expression in the anterior part of the embryo (E) is enhanced in the cement gland and pineal, and in the posterior part (F) in a patch of paraxial mesoderm (pm) and in mesoderm surrounding the cloaca (arrowhead). (G) At neural tube stages, Gadd45γ is expressed in the neural tube, including pineal, and multiple placodes (olf, L, Vp, dlp) [Anterior view]. (H) At neural plate Gadd45γ is expressed in stripes of primary neurons (pn) and the trigeminal placode (Vp) [Dorsal view]. (I) At larval stages, Gadd45α expression becomes weak and diffuse throughout the head and anterior trunk, and is lost from the cement gland. [Side view]. (J) At larval stages, Gadd45γ expression is confined to the brain, retina, anterior spinal cord and placode derivatives (olf, L, crg, oto, ebp) [Side view]. Transverse sections at forebrain (L), hindbrain (M), rostral spinal (K) levels demonstrate neural (fb, r, hb, sc) and placodal (L, oto, crg, ebp) expression.